Trials were conducted in 2005 in High Point, North Carolina, under the direction of Dr. Zoe Draelos using the development name InTon. The trial was to determine the “Efficacy of a Novel Topical MMP Regulator in Aging Skin”. Fifty women participated in the test, with 40 testing the active product against a placebo (a very good botanical base), and 10 testing the product against a cold cream-type placebo. During the study, Dr. Draelos commented “This data set was particularly challenging due to the excellent moisturizing characteristics of vehicle 1” (The Vehicle 1 cream is the same cream being used in our products today).
The study was double blind, randomized, placebo controlled human trials. Each woman used one cream (an active or a placebo) on each side of her face, and neither Dr. Draelos nor the participant knew which cream was active.
At the beginning of the study and at mid-point, each participant was interviewed, photographed, and visually examined. Each side of her face was tested for skin moisture and skin conductivity, and a small silicone mask was taken from each side of her face. Each woman turned in unused product (which was weighed) and a diary of her experience.
Statistical superiority (p=0.015) of the active (with QXP) over vehicle 1 (cream without QXP) was achieved at week 6 in the overall investigator assessment.
Dr. Draelos made very positive comments about the product in her report, and results were dramatic, particularly over the first six weeks.
A note regarding the study. In 2005, the scientific community was just beginning to learn about the many influences of MMP’s on skin aging. In addition, to test the actual level of MMP in skin required a skin puncture, (a wound) that could then be analyzed for MMP levels. Thus, the levels of MMP were not evaluated in the study. Essentially all participants wanted more skin cream at the end of the study (which was provided), and all felt the moisturizing quality of the cream was outstanding.
Agirelox Peptide fights the expression of wrinkles by modulating muscle contraction in the pre-synaptic pathway. It targets two fundamental factors for relaxing muscle contraction and thus attenuating expression wrinkles: reduction of Acetylcholine release while blocking the entrance from calcium ion.
The Arabella Night cream also contains Sodium hyaluronate which a known moisturizing agent and is a natural ingredient which isn’t toxic and won’t harm or irritate skin. Sodium Hyaluronate has a smaller molecular size than Hyaluronic acid, causing it to easily penetrate the skin’s surface, and is able to retain a large amount of water (up to 1,000 its own weight). This means it can penetrate to lower layers of the skin, attract and retain water, and promote nutrient absorption. (Truth in Aging)
Aloe Vera is added for its amino acids. Sodium PCA is a humectant that works as a hydrating agent and a skin-replenishing ingredient. Humectants are ingredients that help the skin to retain and preserve moisture. Humectants work by attracting water to the upper layers of the skin, giving the skin that plumped, hydrated look.
Allantoin contains anti-inflammatories while also acting as an emollient, which means it softens and smoothes the skin. Allantoin also acts as a keratolytic, which means it can improve skin texture and make it feel smoother while also better reflecting the light.
Walnut extract extracted provides the skin with phytic acid, polyphenols, proteins, mineral salts and vitamins. The walnut extract has dynamic activity to protect the cell’s antioxidant pool and has biostimulating properties. It also protects the natural antioxidant pool of the cell. A test was performed on normal human keratinocytes by measuring the intracellular oxidation rate following UV 8 exposure. The cellular oxidation rate was assayed by fluorimetry. It was shown that the walnut extract protects the cell against oxidative stress achieving complete protection. This ingredient protects the antioxidant pool of the cell in the presence of UV-induced oxidative stress, both in vivo and in vitro. Due to its ability to limit the formation and/or the activity of ROS, it protects the skin from environmental aggression such as UV radiation, gaseous pollutants and heavy metals. It provides a preventive effect against extrinsic aging, mostly represented by oxidative stress.
Canadian Willowherb Extract scavenges free radicals (higher efficacy than Trolox, SOD & Vitamin C). Corum tetrapeptide mimics the activity of DHEA, the youth hormone that functions to reverse IL-6 over-production, and therefore reduce the aging symptoms as well as the phenomenon of immunosciencs. It also Arabellas cellular activity. SymSave® is an antioxidant and soothing agent.
Sodium hyaluronate moisturizers when applied topically to skin tissue and is a natural ingredient that isn’t toxic and won’t harm or irritate skin. Sodium Hyaluronate has a smaller molecular size than Hyaluronic acid, causing it to easily penetrate the skin’s surface, and is able to retain a relatively large amount of water- up to 1,000 its own weight. This means it can penetrate to lower layers of the skin, attract and retain water, and promote nutrient absorption. (Truth in Aging)
Agirelox Peptide fights the expression of wrinkles by modulating muscle contraction in the pre-synaptic pathway. It targets two fundamental factors for relaxing muscle contraction and thus attenuating expression wrinkles: reduction of Acetylcholine release while blocking the entrance from calcium ion.
Panthenol is an excellent moisturizer. It functions in several different ways, both as a humectant, attracting water to and holding it in the skin, as well as an emollient, smoothing and softening the skin. SymSave® H is an anti-oxidant and soothing agent.
These active ingredients suspended in our unique delivery system delivers measurable results within days.
